The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care - Concepedia

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The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care

DOI Full Paper Access

54

Citations

34

References

2016

Year

Teresa Paíno, Antonio García-Gómez, Lorena González-Méndez, Laura San‐Segundo, Susana Hernández-García, Ana-Alicia López-Iglesias, Esperanza M. Algarín, Montserrat Martín-Sánchez, David Corbacho, Carlos Ortíz-de-Solórzano,

Clinical Cancer Research

Abstract

Our results demonstrate dual antitumoral and bone-protective effects of PIM447. This fact, together with the very strong synergy exhibited with standard-of-care treatments, supports the future clinical development of this drug in multiple myeloma. Clin Cancer Res; 23(1); 225-38. ©2016 AACR.

References

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