The rs12917707 polymorphism at the <i>UMOD</i> locus and glomerular filtration rate in individuals with type 2 diabetes: evidence of heterogeneity across two different European populations

Abstract

The previously reported strong association between rs12917707 and GFR in diabetic patients from Sweden is not observed in Italian diabetic patients, thus clearly pointing to a heterogeneous effect across the two different samples. This suggests that UMOD is a strong genetic determinant of kidney function in patients with T2D in some, but not all, populations.