Comparative performance of oral midazolam clearance and plasma 4β‐hydroxycholesterol to explain interindividual variability in tacrolimus clearance

Abstract

A MDZ-based model explained more variability in TAC clearance in CYP3A5 non-expressors. However, 4β-OHC/C/W was superior in a model in which no genotype information was available, likely because 4β-OHC/C/W was influenced by the CYP3A4*1b polymorphism.