Concepedia

Sodium Iodide/Hydrogen Peroxide‐Mediated Oxidation/Lactonization for the Construction of Spirocyclic Oxindole‐Lactones

Guofeng Li, Liwu Huang, Jiecheng Xu, Wangsheng Sun, Junqiu Xie, Liang Hong, Rui Wang

Advanced Synthesis & Catalysis · 2016 · 49 citations · 65 references

DOI

Concepts

Abstract

Abstract The sodium iodide/hydrogen peroxide‐mediated oxidation/lactonization of indolepropionic acids was achieved, affording the corresponding spirocyclic oxindole‐lactones in moderate to high yields. This metal‐free procedure features mild reaction conditions, non‐toxicity and easy handling, with hydrogen peroxide (H 2 O 2 ) as a clean oxidant. magnified image

References

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