Influence of <i>Aspergillus fumigatus</i> conidia viability on murine pulmonary micro<scp>RNA</scp> and m<scp>RNA</scp> expression following subchronic inhalation exposure

Abstract

Examination of the pulmonary genetic profiles revealed differentially expressed genes and microRNAs following subchronic inhalation exposure to A. fumigatus. MicroRNAs regulating genes involved in the pulmonary immune responses were those with the greatest fold change. Specifically, germinating A. fumigatus conidia were associated with Clec7a and were predicted to interact with Il13 and Il33. Furthermore, altered microRNAs may serve as potential biomarkers to evaluate fungal exposure.