Melatonin Stimulates the <scp>SIRT</scp>1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (<scp>LPS</scp>)‐Induced Oxidative Stress to Rescue Postnatal Rat Brain

Abstract

These results demonstrated that melatonin treatment rescued the hippocampal DG region of PND7 rat brains against LPS-induced oxidative stress damage, acute neuroinflammation, and apoptotic neurodegeneration via SIRT1/Nrf2 signaling pathway activation.