MedicinePharmacologyPharmacotherapyExperimental PharmacologyNeuropharmacologyPsychopharmacologyDrug DependenceDrugs Of AbuseOpioid PharmacologyPrimate MedicinePsychostimulant PharmacologyRodent PharmacologyAnalgesic Drug MechanismsDose Regimen DesignDose Regimen SelectionPharmacokinetics Of Neuroactive DrugsPrimate PharmacologyRepeated-dose PharmacokineticsRodent Neuropharmacology
For the most part, the procedures described by Seevem and his colleagues (1936, 1963) and Deneau (1956) regarding the facilities and training of the monkey were used and a brief description follows. The monkeys were injected with 3.0, mg/kg S.C. of morphine sulfate every 6 hr for at least 90 days &fore being used, This dose regimen was reported by Seevers and Deneau (1963) to produce maximal physical dependence.