Serum Urea and Creatinine in Diabetic and non-diabetic Subjects

Abstract

Introduction: Diabetic nephropathy is one of the major causes of chronic renal failure. After many years of diabetes the delicate fi ltering system in the kidney becomes gradually destroyed, initially becoming leaky to larger blood proteins such as albumin which are then lost in the urine. Both serum urea and creatinine are widely used to assess the function of kidney. This study was conducted to establish relationship of blood sugar level with urea and creatinine levels, in diabetic and non-diabetic subjects. Materials and Methods: This study was conducted from 2064-4-4 to 2064-7-1 in pathology department of Bharosa diagnostic and research centre.103 diabetic samples and 49 control samples were analyzed for serum urea, creatinine and sugar. Results: 18 out of 103 diabetes samples have high urea level whereas 11 out of 103 had increased creatinine level. In control only one sample had high urea value and two had high creatinine level. There was statistical signifi cant increased in urea level with increased in blood sugar level (p<0.05, 95%CI) Conclusion: Strong relationship of blood urea level was found with blood sugar level. To monitor the diabetes patients, estimation of blood urea level along with blood sugar level could be important.