Photocatalytic Radical Trifluoromethylation/Cyclization Cascade: Synthesis of CF₃-Containing Pyrazolines and Isoxazolines

Abstract

A general visible light induced photoredox-catalyzed radical trifluoromethylation/cyclization cascade of β-aryl-β,γ-unsaturated hydrazones and oximes is described. The protocol enables an efficient access to various densely functionalized and biologically important CF3-containing dihydropyrazoles and isoxazolines with generally high yields.