PharmacyPediatricsPharmacotherapyPediatric Clinical PharmacologyPediatric Emergency CarePediatric PharmacotherapyAdverse Effects Of AnalgesicsPediatric Analgesic TherapyPediatric Drug DosingPediatric Patient SafetyPediatric SedationSedation ComplicationsPediatric Analgesic SafetyPediatric Emergency SedationPediatric Sedation ComplicationsRisk AppraisalSedation Adverse EventsSedation For Pediatric PatientsSerious Adverse Drug ReactionsSerious Adverse Events
Since the use of narcotics was initially advocated 28 years ago, serious adverse reactions, including fatalities, have been reported. At least four factors appear to contribute to these reactions: multiple drug administration, excessive dosage, inadequate monitoring, and ineffectual emergency care. Because of the relatively high incidence of life-threatening reactions and the complexity of the required emergency care, the routine use of pediatric sedation techniques that require large doses of narcotics cannot be advocated for use in the private office.
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Lidocaine in the Prevention of Primary Ventricular Fibrillation
K. I. Lie, Hein J.J. Wellens, F J van Capelle et al. · New England Journal of Medicine · 1974 · 443 citations
Medicine, Cardiology, Pharmacology +13
EFFECTS OF CONVULSANTS ON ENERGY RESERVES IN THE CEREBRAL CORTEX *
Lucy Jane King, O. H. Lowry, Janet V. Passonneau et al. · Journal of Neurochemistry · 1967 · 181 citations