PubMed · 1985 · 31 citations · 0 references
PharmacyBiochemistryMedicinal ChemistryBiophysical ChemistryMolecular OncologyNucleic Acid ChemistryDna ChemistryDna StructureFluorescence SpectroscopyAnthracycline-based ChemotherapyDna-drug InteractionsFluorescent ProbesStereochemical DescriptorsStereochemical MechanismsStereochemical Requirements
The DNA affinity for 26 anthracycline derivatives was studied by the quenching fluorescence technique. The stereochemical requirements for DNA intercalation are discussed. The relationship between the DNA affinity and bioactivity is also pointed out.