Human Myelogenous (Ph 1 +) Leukemia Cell Line: Into Athymic Mice 2

Abstract

Chronic myelogenous leukemia (CML) cells from line K-562, containing the Philadelphia (Ph1) chromosome, were transplanted into nude mice and grew as solid vascularized tumors containing cells like those seen in the patient and in the cultures. Cells taken from the tumors were near triploid and retained all human chromosome markers in culture.