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Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans

Metabolic SyndromeInsulin SignalingSystems BiologyMolecular PhysiologySignal TransductionHealth SciencesSkeletal MuscleNutrient SignallingPhysiologyDiabetesMetabolic SignalingAmpk/sirt1 PathwayMetabolic RegulationMetabolic RemodelingMetabolismMedicineCell SignalingLeucine–metformin Combination Increases