Circadian and ultradian patterns of epileptiform discharges differ by seizure‐onset location during long‐term ambulatory intracranial monitoring

Abstract

Epileptiform activity has a strong 24 h periodicity with peak nocturnal occurrence. Limbic and neocortical epilepsy show divergent circadian influences. These findings confirm that circadian patterns of epileptiform activity vary by seizure-onset zone, with implications for treatment and safety, including SUDEP.