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Persistent intravascular C3 activation after bilateral nephrectomy in patients with thrombotic microangiopathy.
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1976
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VasculitisImmunologyPathologySurgeryThrombosisHematologyVascular SurgeryNeurologyC3-splitting ActivityMicrovascular DysfunctionIntravascular C3 ActivationImmune ComplexesAutoimmune DiseaseAutoimmunityVascular BiologyThrombotic MicroangiopathyBilateral NephrectomyMedicineNephrologyKidney Research
Four patients with thrombotic microangiopathy had evidence of intravascular C3 activation on presentation which persisted after bilateral nephrectomy. In several serum samples, C3-splitting activity was not associated with the presence of circulating immune complexes, which were detected in all four patients before nephrectomy and in three after nephrectomy.