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A more detailed map of the cystic fibrosis mutation DF508 frequencies in Europe.
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1993
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Southeast European PopulationsGeneticsGenetic EpidemiologyDiagnosisPathologyDisease Gene IdentificationClinical GeneticsMendelian DisorderDf508 Mutation VariesPublic HealthPopulationDf508 MutationDetailed MapStatistical GeneticsPulmonary FibrosisGenetic VariationPopulation GeneticsEpidemiologyGenetic DisorderMedical GeneticsMedicine
When analyzed by origin, the frequency of the DF508 mutation (the main cystic fibrosis mutation) varies between population groups. We show here that the frequency of the DF508 mutation varies among different populations, being higher in northwest Europeans than in southeast European populations. The map we have constructed covers 25 countries; isofrequency curves were calculated using an original method.