Life SciencesEndocrinologyPhysiologyMetabolic PhysiologyMetabolic RegulationMetabolismAdipose TissueHormonal Control Of MetabolismHormonal RegulationHormone MetabolismMetabolic EndocrinologyRodent PhysiologyAdipocyte BiologyAdipose Tissue EndocrinologyBrown Adipose Tissue BioenergeticsBrown Adipose Tissue MetabolismHormonal Regulation Of Thermogenesis
The defective BAT function of obese Zucker rats has been related primarily to a loss of diet-induced thermogenesis. The normalisation of BAT function by adrenalectomy has been related to the removal of corticosterone. Experiments with propranolol-blockade and on tissue norepinephrine turnover suggest that corticosterone impairs diet-related sympathetic activity but does not alter BAT response to exogenous norepinephrine. The reduction in serum T3 in obese rats is related to the loss of sympathetic activity.