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[The CHARGE association].
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1989
Year
Corticobasal DegenerationVascular MalformationPathologyLawCriminal LawAnatomyVisceral MalformationsGross AnatomyLegal AssessmentMendelian DisorderLegal ProcessNeurologyNeuropathologyDi George SyndromeCharge AssociationPublic PolicyNeuromuscular PathologyDevelopmental AnomalyGenetic DisorderNeuroanatomyNeuroscienceMedicine
The CHARGE association includes a group of several malformations, and always a coloboma and/or choanal atresia. We present 8 cases of this syndrome, 5 complete and 3 incomplete forms. Prognosis at term seems severe, considering the visceral malformations (namely cardiac) and the cerebral handicap often associated. In most cases the CHARGE association is a sporadic event; however, one cannot exclude the possibility that certain forms follow a Mendelian pattern of inheritance. The mechanisms leading to this association have not yet been elucidated: it is probably due to migration abnormalities of the neural crests as in the VATER association of Di George syndrome.