Association of BCL11A genetic variant (rs11886868) with severity in β-thalassaemia major & sickle cell anaemia

Abstract

This study confirms that the T/C variant (rs11886868) of the BCL11A gene causing downregulation of BCL11A gene expression in adult erythroid precursors results in the induction of HbF and ameliorates the severity of β-thalassaemia as well as SCA.