Japanese Journal of Clinical Oncology · 1978 · 11 citations · 0 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyPharmacokinetics Of Anticancer AgentsAntitumor AntibioticsChemotherapy Drug AdministrationHematologic Malignancy PharmacotherapyIntravenous Anticancer Drug PharmacokineticsOncology PharmacologyPharmacokinetics Of Anticancer DrugsChemotherapy-induced Gastrointestinal ToxicityChemotherapy-related ToxicityDose-time RelationshipIntravenous Chemotherapy DosingPharmacokinetics Of Cytotoxic ChemotherapyToxic Dose Assessment
A phase 1 study of aclacinomycin A was performed in a series of 22 patients with incurable malignant tumors. Aclacinomycin A was injected intravenously at a dose ranging from 15 to 70mg/m2. The toxic reactions encountered were anorexia, nausea, vomiting, leukopenia, and thrombocytopenia, but they were mild and transient. A dose-toxicity relationship was mainly observed in thrombocytopenia and leukocytopenia. Only the transient T wave depression was observed when 40 mg/m2 of aclacinomycin A was given intravenously. The highest non-toxic single dose of aclacinomycin A might be 70 mg/m2.