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Primary cutaneous B cell lymphoma during methotrexate therapy for rheumatoid arthritis.
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2000
Year
Rheumatoid DisorderRheumatologyLymphoid NeoplasiaAutoimmune DiseaseMalignant Blood DisorderImmunologyPathologySkin LesionsClinical DermatologyDermatologyDermatopathologySclerodermaMedicineClinical AwarenessRheumatoid ArthritisMethotrexate Therapy
A patient with rheumatoid arthritis developed a reversible, primary cutaneous, large B cell lymphoma during prolonged methotrexate (MTX) treatment. Regression of the skin lesions after discontinuation of the drug suggested a close relationship to MTX. Increased clinical awareness, discontinuation of MTX, and close observation are important in the initial management of this rare lymphoproliferative disorder.