Journal of the American Veterinary Medical Association · 1991 · 45 citations · 0 references
MedicineImmunologyVeterinary PharmacologyEquine MedicineImmunopathologyImmunopharmacotherapyHematologic ToxicityImmunomodulatory Drug TherapyImmunomodulatory DrugsImmunosuppressionVeterinary ImmunologyVeterinary ImmunopharmacologyEquine PharmacologyImmune-mediated Thrombocytopenia
Azathioprine, a thiopurine antimetabolite used in the treatment of immune-mediated thrombocytopenia in human beings and dogs, was used in 2 cases of immune-mediated thrombocytopenia in horses that failed to respond to corticosteroid therapy alone. Platelet counts were increased to acceptable values in both horses. One horse returned to a successful racing career, and the other was euthanatized after developing renal disease and mild laminitis.