PubMed · 2005 · 23 citations · 0 references
PharmacyInfectious DiseasesPharmacotherapyImmunology Of Infectious DiseasesImmunopharmacologyInfectious Disease PharmacotherapyAntiviral ImmunityAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyPulmonary InfectionsRespiratory Infectious DiseasesAntiviral TherapeuticsDeath Rate AnalysisInfluenza PneumoniaInfluenza TreatmentIntranasal AdministrationIntranasal ApproachLung Consolidation AssessmentRhinovirus Infection
OBJECTIVE: To study anti-influenza virus effect of Arctigenin in vivo. METHODS: The influences on lung index, death rate of mice infected by influenza virus were observed in the mice infected with virus from nose. RESULTS: Experiments in vivo showed that Arctigenin at the concentration of 100 microg/kg and 10 microg/kg for the intranasal treatment markedly inhibited the lung consolidation of mice pneumonia caused by the infection of influenza virus. Arctigenin at the concentration of 100 microg/kg prolonged the survival time of mice infected with influenza virus. CONCLUSION: Arctigenin may be effective on treating influenza.