Long‐term potentiation–like cortical plasticity is disrupted in Alzheimer's disease patients independently from age of onset

Abstract

Cortical LTP disruption is a central mechanism of AD that is independent from age of onset. AD can be described primarily as a disorder of LTP-like cortical plasticity not influenced by physiological aging and associated with a more-severe cognitive decline. Ann Neurol 2016;80:202-210.