Synthetic Communications · 2016 · 28 citations · 16 references
Natural SciencesChemistryBiocatalysisCatalysisEnzymologyCatalytic MechanismsMetal CatalysisOrganic SynthesisRedox CatalysisRedox ChemistryRedox ReactionsCopper-catalyzed CouplingCopper-catalyzed OxidationMetal Oxide CatalysisMetal-catalyzed OxidationMild Reaction ConditionsRadical Reaction MechanismsTransition Metal-catalyzed Synthesis
A simple and facile copper-catalyzed synthesis of β-ketophosphine oxides via direct oxyphosphorylation of alkynes with H-phosphine oxides and dioxygen has been developed under mild conditions without any base or cocatalyst. A radical reaction pathway for the formation of β-ketophosphine oxides is proposed. An 18O labeling experiment suggested that the carbonyl oxygen atom of β-ketophosphine oxides originated from dioxygen.
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