Copper-Catalyzed Intramolecular Dehydrogenative Amidation of Unactivated C(sp³)–H Bonds Using O₂ as the Sole Oxidant

Abstract

In this work, an aerobic copper-catalyzed intramolecular C(sp(3))-H amidation has been disclosed, which presents a rare example of copper-catalyzed functionalization of an unactivated C(sp(3))-H bond with O2 as the sole oxidant. In addition, a new protocol for the preparation of a removable 5-methoxyquinolyl moiety has been documented.