The Role of the Spleen in the Leukocytosis Following the Intra-arterial Administration of Epinephrine

Abstract

tractility of the spleen atsd it-s sequestered cellular cotitetst. The literature dealing with this concept is cotstroversial, confirming or detsying the observatiotis. Harvey’s cotsclusions’ svere based ots single experimeists ots a clog, cat atsd rabbit. Frey2 believed that the lymphocyte response was a futsctional test of the contractility of the spleets hut it is too complicated to be explaitsed simply by splenic contractiots. Barcroft3 s�’as unable fully to support- Harvey or Frey’s conteistiots from his data despite his extetssive studies of the spletsic circulatiots in the dog. Camp4 foutsd the lymphocytosis follow’ing pilocarpitse admitsistration iti splenectomized patients to he as profoutid as w’hets the spleets ss’as present. Similar data were obtained in other animals.’7 Lucia arid his associates8 supplied the most conclusive data refuting Frey’s test as a function of spletsic cotstractility its mats when they found similar leukocytoses following subcutatseous epinephritie administratiots in 4 patietsts both