Chemical Communications · 2016 · 45 citations · 42 references
PharmacyMedicinal ChemistryOncologyDrug DeliveryDrug DesignProdrug DesignAnticancer Prodrug DesignCancer Drug DeliveryDrug Delivery EngineeringDrug Targeting StrategiesTargeted Prodrug DeliveryTumor-activated ProdrugsChemotherapeutic Prodrug DesignEx Vivo DeliveryEx Vivo ModelsProdrug-drug ConjugatesTargeted Chemotherapy ProdrugsTargeted Drug ActivationTargeted Drug Delivery ProdrugsTumor-targeted Prodrugs
An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.
42