Inhibition of apomorphine‐induced vomiting by benzquinamide

Abstract

Benzquinamide was compared to prochlorperazine in apomorphine‐induced vomiting in healthy male volunteers. The antiemetic activity of benzquinamide by the oral route was significantly greater than that of 10 mg. of prochlorperazine. On the other hand, duration of action of benzquinamide was much shorter than that of prochlorperazine. Vomiting was not prevented except in a small percentage of the subjects 6 to 12 hours after oral administration of benzquinamide, while prochlorperazine was still effective. There were no adverse effects after benzquinamide. Benzquinamide is an effective antiemetic with rapid onset of action that deserves further clinical trial.