PubMed · 2006 · 20 citations · 9 references
MedicineOncologyPharmacologyBreast OncologyMetastasisMolecular OncologyBreast Cancer OncologyChemotherapy ResistanceMetastatic Breast CancerTherapeutic ResistanceAtp-binding Cassette TransportersBreast Cancer Endocrine TherapyBreast Cancer Hormonal TherapyDisease-free Survival AssessmentDrug Efflux PumpsMultidrug Efflux PumpsTumor Suppression MechanismsTumor Suppression Pathways
BACKGROUND: The ATP binding cassette (ABC) family acts as efflux pumps and some members are related to chemoresistance in breast cancer. The clinical role of ABCF2 expression, a member of the ABC family, was analyzed. MATERIALS AND METHODS: One hundred and ninety-one patients with breast cancer were enrolled. The median follow-up term was 76 months. ABCF2 expression was examined by immunohistochemistry. RESULTS: Ninety percent of the breast cancer cases displayed immunoreactivity for ABCF2. The positive rate of ABCF2 expression was 63%. ABCF2 had a negative relationship to distant metastasis. ABCF2-positive tumors had longer disease-free survival (DFS) than -negative tumors in patients with lymph node metastasis (p = 0.001). In patients treated with endocrine therapy, ABCF2-positive tumors had a longer DFS when the tumors were estrogen receptor-negative or progesterone receptor-negative (p = 0.0019 and 0.005, respectively). CONCLUSION: ABCF2 was initially thought to be related to drug resistance. ABCF2 may play a role in tumor suppression at metastatic sites and in the endocrine pathway for breast cancer.
9
Alteration in Copy Numbers of Genes as a Mechanism for Acquired Drug Resistance
Kohichiroh Yasui, Saori Mihara, Chen Zhao et al. · Cancer Research · 2004 · 220 citations