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How to Study Boron Biodistribution in Liver Metastases from Colorectal Cancer
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2004
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Boron DistributionPathologyLiver MetastasesOncologyHepatobiliary TumorStudy Boron BiodistributionRadiation OncologyNuclear MedicineCancer ResearchRadiologyHealth SciencesRadiation TherapyLiver PhysiologyColorectal CancerBoron AdministrationHepatologySelective Boron DistributionHepatitisLiver CancerMedicineHepatocellular Carcinoma
The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: alpha particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.