Expression of the mismatch repair protein hMSH2 in carcinoma in situ and invasive cancer of the breast.

Abstract

During development from in situ to invasive cancer of the breast, hMSH2 expression seems to be downregulated. However, in invasive cancer, hMSH2 expression seems to be associated with tumor progression. This could be explained by the fact that enhanced proliferation of tumor cells results in increased mistakes within DNA replication procedures.