PubMed · 1985 · 61 citations · 0 references
MedicineDevelopmental BiologyObstetricsEmbryologyObstetric UltrasoundPrenatal DiagnosisCongenital Brain MalformationsCongenital Cranial AnomaliesCongenital MalformationsFetal AnomaliesFetal Anomaly DetectionFetal PresentationCongenital Cranial MalformationsFetal Brain AssessmentFetal Brain MalformationsFetal Central Nervous System MalformationsFetal Head UltrasonographyFetal Structural Anomaly DetectionPrenatal Diagnosis Of MalformationsStructural Defects
The holoprosencephalies are a spectrum of cerebral and facial malformations resulting from incomplete division of the embryonic forebrain. Using ultrasound to search for structural defects in the fetal brain and to measure interorbital distances, the alobar variety can be diagnosed antenatally. A series of seven cases is presented. Criteria for diagnosis and guidelines for obstetric management are presented.