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Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles
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References
1959
Year
Muscle FunctionBiomedical EngineeringBlood FlowK 42Fick PrincipleSkeletal MuscleBlood Flow MeasurementCapillary NetworkAnimal PhysiologyVeterinary PhysiologyHypertonicityMolecular PhysiologyBiochemistryTissue PhysiologyVascular BiologyPotassium HomeostasisPhysiologyVeterinary ScienceElectrophysiologyMedicine
The study uses isolated perfused dog muscles to measure blood flow, arteriovenous K‑42 differences, and calculate blood‑tissue clearance via the Fick principle, and develops a theoretical relation between flow and clearance assuming a uniform circulation with constant PS. Experimental data largely agree with the theoretical prediction, yet systematic changes in the PS product with flow and resistance reveal that the capillary circulation is not uniform.
A method is described for studying transcapillary diffusion of K 42 in isolated perfused muscles of dogs. Blood flow and arteriovenous K 42 differences are measured and blood-tissue clearance calculated by the Fick principle. A theoretical relation between blood flow and blood-tissue clearance is developed for a uniform circulation characterized by a constant permeability—surface area product (PS). The experimental observations conform reasonably closely to prediction. However, systematic variation in measured PS product with changes in blood flow and vascular resistance indicate that the capillary circulation is not uniform.