Elevated maternal serum alpha-fetoprotein in triploidy.

Abstract

We report two cases of greatly elevated maternal serum alpha-fetoprotein (MSAFP) in pregnancies associated with a triploid fetus. The concentration of AFP in amniotic fluid and fetal serum was within the normal range. Determination of fetal karyotype provides the only definitive method of diagnosis. Prompt recognition is warranted in view of the high rate of severe preeclampsia in triploid pregnancy.