Publication | Open Access
Gold‐Catalyzed Cycloisomerization of Alkyne‐Containing Amino Acids: Controlled Tuning of C–N vs. C–O Reactivity
12
Citations
40
References
2016
Year
Combinatorial ChemistryCross-coupling ReactionEngineeringAmino AcidsBiochemistryAmbident PrecursorsNatural SciencesAlkene MetathesisAlkyne‐containing Amino AcidsOrganic ChemistryOrganometallic CatalysisCatalysisDivergent SynthesisChemistryC–o ReactivitySynthetic ChemistryBiomolecular Engineering
Versatile alkyne‐containing amino acids were used as ambident precursors in the divergent synthesis of alkylidenelactones and 1‐pyrrolines. Two gold‐catalyzed protocols were applied for selective intramolecular O‐ and N‐cycloisomerization reactions.
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