Organic & Biomolecular Chemistry · 2016 · 45 citations · 28 references
Natural SciencesBioengineeringMicrobiologyDrug DeliveryNanobiotechnologyNanomaterialsCalixarene ChemistryInorganic NanoparticlesNanobiomaterialsNanomaterials For Drug DeliveryNanoparticle DesignSelf-assembly Of NanomaterialsAntibacterial NanomaterialsAntimicrobial NanomaterialsBactericidal AgentsHydrophobic InteractionsNanoparticle Antimicrobial AgentsNanoparticle-based AntimicrobialsPolymeric CalixarenesVisible Light Effects
A hydrophobic N-dodecyl-3-(trifluoromethyl)-4-nitrobenzenamine has been synthesized as a suitable NO photodonor and encapsulated in a nanocontainer based on a polycationic calix[4]arene derivative, leading to a supramolecular micellar-like nanoassembly ca. 45 nm in diameter. Visible light excitation of this nanoconstruct triggers NO generation with an efficiency remarkably higher than that observed for the free NO photoreleaser. This amplified NO release results in considerable antibacterial activity against Staphylococcus aureus (ATCC 6538) and Pseudomonas aeruginosa (ATCC 9027) as representative Gram positive and Gram negative bacteria, respectively.
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Antibiotic resistance—the need for global solutions
Ramanan Laxminarayan, Adriano Dusé, Chand Wattal et al. · The Lancet Infectious Diseases · 2013 · 4.4K citations · Full text
Gary Taubes · Science · 2008 · 749 citations