Irradiation of Mouse Skin With Single Doses of Ultraviolet Light2

Harold F. Blum, Elmer Butler, Thomas H. Dailey, Jasper R. Daube, Richard C. Mawe, Gerald A. Soffen

JNCI Journal of the National Cancer Institute · 1959 · 14 citations · 0 references

Concepts

Abstract

Changes in the ears of albino mice, following single exposures to polychromatic ultraviolet radiation, have been studied with a method that insures uniformity of incident dosage. Gross and histological changes and quantitative evaluation of hyperplasia indicate a pattern of inflammatory lesion followed by healing processes, but with certain special characteristics that may be associated with the restriction of the primary action of the radiation to a very thin layer. Relationships of these studies to the induction of cancer by repeated doses of ultraviolet radiation are discussed.