Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122

Abstract

Given the widespread expression of TRPM4 and TRPM3 channels, these actions of U73122 must be considered when interpreting its effects on cell function. U73122 may also be useful for identifying and characterizing TRPM channels in native tissue, thus facilitating the analysis of their physiology.