Suppression of the hypothalamic-pituitary-adrenal axis after a single intramuscular injection of methylprednisolone acetate.

Abstract

Fourteen patients with hay fever were treated with one intramuscular injection of methylprednisolone acetate, which gave satisfactory symptomatic relief for three weeks. Their hypothalamic-pituitary-adrenal function was moderately but significantly suppressed for three weeks but became normal again after four weeks.