PHRAMACOLOGICAL EVALUATION OF 1-(N, N-DISUBSTITUTED AMINOMETHYL)-3-IMINO-(2-PHENYL-3,4-DIHYDRO-4-OXO-QUINAZOLIN-3-YL) INDOLIN-2-ONES

Abstract

Eleven new Mannich bases of isatins were screened for potentiation of pentobarbitone-induced narcosis, anaigesic, antidepressant, anticonvulsant and H1-antihistaminic activities. The test compounds were found to exhibit a moderate analgesic activity and also to potentiate the pentobarbitone-induced narcosis. However, these compounds were found to be devoid of antidepressant, anticonvulsant and antihistaminic activities.