PubMed · 1987 · 13 citations · 0 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyGastrointestinal OncologyChemotherapy Drug AdministrationDose SchedulingEsophageal CancerGastrointestinal Cancer PharmacotherapyChemotherapy Dose IntensityGastric Cancer PharmacotherapyPhase Ii InvestigationPilot Study DesignRecommended Phase 2 DoseRecommended Phase Ii Dose
In a pilot study 16 patients with advanced inoperable stomach cancer were treated with Etoposide, Adriamycin, Cisplatin. The recommended dose for phase II studies was established and first therapy results are presented. Two of 16 patients responded with complete remissions and 8 with partial remissions. The recommended dose schedule for phase II studies is: Adriamycin 20 mg/m2 i.v. day 1 + 7; Cisplatin 40 mg/m2 i.v. day 2 + 8; Etoposide 120 mg/m2 i.v. day 4, 5, 6, every four weeks.