[Preliminary linkage analysis and mapping of keloid susceptibility locus in a Chinese pedigree].

Abstract

Among the 7 markers, the two-point LOD scores of 5 ones (D15S108, D15S216, D15S534, D18S363, D18S846) were less than -2 at theta = 0, they were excluded the linkage to the disease locus; but the scores of other two (D18S460, D18S467) were either more than 1 at theta = 0.05 & 0.10 and D18S460 was 2.201, which showed linkage to the disease locus in some extent. Conclusions This study firstly reported and provided some evidence that keloid susceptibility locus of Chinese family maybe on chromosome 18q21.1, SMAD and PIAS2 may be the possible genes.