In Vivo MRI and X‐Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO₄·H₂O Nanobundles for Tracing Bone Implant and Bone Regeneration

Abstract

Homogeneous and monodisperse GdPO4 ·H2 O nanobundles are successfully synthesized via a solvothermal method. Then, GdPO4 ·H2 O are incorporated into the composite of hydroxyapatite and poly(lactic-co-glycolic acid) to obtain a biodegradable and traceable bone implant. After implanted, the GdPO4 ·H2 O/HA/PLGA implant and the newly formed bone can be easily traced and observed through the combination of magnetic resonance imaging and X-ray imaging.