Non Random Distribution of <i>DMD</i> Deletion Breakpoints and Implication of Double Strand Breaks Repair and Replication Error Repair Mechanisms

Abstract

Our results illustrate, in a large series of patients, the important role of RE and other genomic features in DNA breaks, and the involvement of different mechanisms in DMD gene deletions: Mainly replication error repair mechanisms, but also NHEJ and potentially aberrant firing of replication origins. A combination of these mechanisms may also be possible.