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Effect of caffeine on cardiac contractile activity and radiocalcium movement
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1963
Year
Cardiac MuscleCardiovascular FunctionElectrophysiological EvaluationKinesiologyPositive Inotropic ResponseApplied PhysiologyCardiologyCardiac MechanicHealth SciencesCardiac Contractile ActivityIon ChannelsNeurophysiologyPhysiologyElectrophysiologyCardiovascular PhysiologyNeuroscienceToad Ventricular MuscleMedicineCa 45
Caffeine induced a positive inotropic response in toad ventricular muscle. The magnitude of the inotropic response was influenced by the concentration of Na + and Ca ++ in the perfusate and by the rate of stimulation. Caffeine abolished poststimulation potentiation and the "staircase" phenomenon, and evoked an increase in the inward and outward movement of Ca 45 . The positive inotropic activity of caffeine can be related to the changed movement of Ca ++ .