Human antibody reactivity against xenogeneic <i>N</i>‐glycolylneuraminic acid and galactose‐α‐1,3‐galactose antigen

Abstract

We showed that IgG-mediated CDC was detected in Neu5Gc-overexpressed HEK293 cells incubated with human sera; however, this antibody reactivity to Neu5Gc was highly variable among individuals. Our results suggest that additional modifications to the CMAH gene should be considered for widespread use of pig organs for human transplants.