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Zwitterionic-Type Molten Salt Catalyzed Iodination in Water: Synthesis of Iodoimidazoheterocycles
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2016
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Imidazole ScaffoldsChemical EngineeringDiversity Oriented SynthesisEngineeringHeterocyclicBenign ProtocolNatural SciencesDiversity-oriented SynthesisMolecular IodineOrganic ChemistryCatalysisChemistryHeterocycle ChemistrySynthesis MethodSynthetic ChemistryCatalytic Synthesis
An environmentally benign protocol for the iodination of imidazoheterocycles has been developed through sp<sup>2</sup> C–H bond functionalization with molecular iodine in water at room temperature. The reaction is catalyzed by an imidazole-based zwitterion-type molten salt. A library of iodo-substituted imidazo[1,2-<i>a</i>]pyridines with broad functionality have been synthesized. This methodology is also applicable to imidazo[2,1-<i>b</i>]thiazole and imidazole scaffolds.