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Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.
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1984
Year
Chemoprevention StrategyCellular PhysiologyTumor BiologySignaling PathwayCell RegulationReceptor Tyrosine KinaseCancer Cell BiologyCellular Regulatory MechanismReceptive ProteinCell SignalingBiochemistryPharmacologyCell BiologyTumor MicroenvironmentProtein PhosphorylationSignal TransductionPhorbol Ester TpaMedicineTumor Promoter
The phorbol ester TPA may be intercalated into the membrane phospholipid bilayer and selectively binds to every molecule of C-kinase in exhibiting its full enzymatic activity. Available evidence suggests that C-kinase is the receptive protein of this tumor promoter, and the results presented seem to provide clues for clarifying the mechanism of controlling cell growth and differentiation.