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A synergistic interaction between magnesium sulphate and ketamine on the inhibition of acute nociception in rats.

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Citations

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References

2015

Year

Katarina Savić Vujović, Sonja Vučković, Dragana Srebro, Branislava Medić, Rastko Stojanović, Čedomir Vučetić, Milica Prostran
PubMed

Abstract

This study revealed that (1) magnesium sulphate and ketamine given alone were not effective against acute nociceptive pain in rats, but (2) a combination of both drugs resulted in synergistically inhibited nociception, (3) which occurred only at selected low doses and proportions of the medications in a combination and (4) suggested the importance of the order of drug administration.